![]() Rio (Jorge Cruz), Taylor Nichols (Rick Humphrey), Brent Sexton (Jerry Frost), Jonathan Scarfe (Hank), Kathryn Joosten (Mrs. Notable Guest Stars: Skyler Shaye (Katie Bryce), Alice Lo (Qing Lu), Keith David (Lloyd Mackie), Callum Blue (Viper), Anna Maria Horsford (Liz Fallon), F.J. (Richard Webber), Isaiah Washington (Preston Burke), Patrick Dempsey (Derek Shepherd) Knight (George O'Malley), Chandra Wilson (Miranda Bailey), James Pickens, Jr. ![]() Regular Cast: Ellen Pompeo (Meredith Grey), Sandra Oh (Cristina Yang), Katherine Heigl (Isobel "Izzie" Stevens), Justin Chambers (Alex Karev), T.R. Creator: Shonda Rhimes / Directors: Peter Horton, Tony Goldwyn, Adam Davidson, John David Coles, Scott Brazil, Darnell Martin, Sarah Pia Anderson, Wendey Stanzer
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